Careers

• Work on projects that involve the screening and engineering the bispecific antibodies to improve their functional activities.
• Responsible for transient and stable transfection on mammalian cell lines for protein/antibody expression.
• Responsible for ELISA, immunofluorescence staining, DNA/RNA extraction and purification, cloning and PCR techniques, RNA/DNA sequencing for project requirement.
• Support coordinating vendors and conducting new vendor search.
• Perform other items requested by supervisors.

• Responsible for establishing strategy for the development of antibody and antibody-drug candidate (ADC)
• Work closely with CSO on forming strategic plan to develop next generation candidates
• Identification of potential targets for antibody development
• Up stream process of antibody development includes antibody construct design/engineering, characterization and production to evaluate the draggability of the antibody.
• Downstream process of antibody development includes cell line development, clone selection, and identification of top clones with high titer for antibody production to evaluate the developability of the antibody.
• Conduct mechanism of action studies to explore potential interactions of multiple targets
• Conduct in vivo study to evaluate the antitumor efficacy of the antibody-drug conjugate (ADC) that derived from the antibody developed
• Supervise multiple functional teams and provide strategic guidance for the teams
• Ensure cross functional collaborations within the department as well as with other departments
• Execute the projects efficiently and make sure the objectives are delivered in a timely fashion
• Serve as team lead for antibody and antibody-derived drug discovery, engineering, early antibody process development, and characterization of the activity for candidate drug selection.
• Serve as team lead for CRO selection on antibody discovery that align with the organization’s goals and objectives.
• Support antibody manufacturing CDMO selection.
• Take responsibility on tech transfer of antibody upstream process development protocol for manufacturing.
• Support document preparation for IND application.

• Support oncology drug discovery programs through design and synthesis of potential drugs.
• Design and synthesize potential linkers, payloads, and platform for antibody-drug conjugates (ADC) development.
• Support the synthesis, purification, and characterization of organic compounds.
• Operate a variety of analytical instruments including HPLC, NMR to enable structural determination and purity assessment.
• Ability to foster teamwork and actively participate in the review of projects with colleagues throughout the organization.
• Stay up to date with literature in synthetic chemistry, medicinal chemistry, and ADC field.
• Must be an independent and self-motivated scientist.

• Design and develop modular strategies compatible for rapid access to small molecule targets (strong organic synthesis background is required)
• Learn and employ medicinal chemistry strategies that will enable the discovery of novel, differentiated small molecule and linker candidates for tumor targeted delivery by incorporating optimal structural, pharmacological, physicochemical, metabolic, and safety considerations.
• Prioritize deliverables and projects in fast-paced and dynamic environment.
• Demonstrate creativity, problem-solving and critical thinking skills to overcome challenges all while building/strengthening IP.
• Closely collaborate with project team members and leverage in house resources to meet timelines.
• Regularly attend, present, and actively participate in group meetings as well as write project update reports and participate in writing and submission of patent applications, peer-reviewed articles.
• Stay up to date with literature and patents in synthetic organic chemistry and drug development, advances in medicinal chemistry or ADC field, and advances in broader modalities that influence oncology research.