Announcement of issue price and banks designated to collect and deposit the proceeds

The Active Cancer Immunotherapy OBI-822, has been granted by ANVISA of Brazil to proceed to Phase III Clinical Trial

Supplementary statements on news article

Announcement of preclinical animal study results of OBI’s COVID-19 vaccine

The Active Cancer Immunotherapy OBI-822, has been granted by URPL of Poland to proceed to Phase III Clinical Trial

Announcement of reference date of 2022 cash capital increase and share subscription

The Active Cancer Immunotherapy OBI-822, has been granted by AEMPS of Spain to proceed to Phase III Clinical Trial

The Active Cancer Immunotherapy OBI-822, has been granted by DIGEMID of Peru to proceed to Phase III clinical trial

OBI has filed the application for a Phase II clinical trial for OBI-833, an active cancer immunotherapy, to TFDA

OBI in-licensed “anti-Trop2 antibody” exclusive rights from Biosion